After engineering a daring escape from the hellish, Panamanian prison Sona, brothers MICHAEL SCOFIELD (Wentworth Miller) and LINCOLN BURROWS (Dominic Purcell) are determined to seek justice against The Company, the shadowy group responsible for destroying their lives and killing the woman Michael loves, DR. SARA TANCREDI (Sarah Wayne Callies).
Michael’s quest for vengeance leads him to Los Angeles, where his world is turned upside down when Company operative GRETCHEN/SUSAN B. ANTHONY (Jodi Lyn O’Keefe) informs him that Sara is still alive. Realizing the only way they will truly be free, Michael and Lincoln avow to find Sara and take down The Company by stealing the organization’s “black book.” With the help of Homeland Security agent DON SELF (Michael Rapaport), they assemble a group of allies and familiar faces to accomplish their task: MAHONE (William Fichtner), SUCRE (Amaury Nolasco), BELLICK (Wade Williams) and computer expert ROLAND GLENN (James Hiroyuki Liao).
Unfortunately for the brothers, they must also evade Company assassin WYATT (Cress Williams) and find an on-the-loose T-BAG (Robert Knepper), who unknowingly possesses a vital clue to help them pull off their most difficult challenge yet.
Michael and Lincoln soon discover the only thing harder than breaking out will be breaking in.
PRISON BREAK, shot in Los Angeles, is an Adelstein-Parouse Production in association with 20th Century Fox Television. Paul T. Scheuring, Matt Olmstead, Kevin Hooks, Marty Adelstein, Dawn Parouse, Neal Moritz and Brett Ratner are executive producers. Zack Estrin and Nick Santora are co-executive producers.